Endocrine Abstracts

Background: Parathyroidectomy for primary hyperparathyroidism (PHPT) is followed by a decrease in the severity of symptoms reported on the Pasieka’s parathyroid symptoms score (PPSS) questionnaires and such changes correlate with improved quality of life assessed by the SF36 questionnaire (World J Surg 2008 32 807). Some argue that these benefits are short-lived and only apparent in the first months postoperatively.Aim: To determine wh...

Background: Mild primary hyperparathyroidism (PHPT) is frequently diagnosed in patients with minimal hypercalcaemia whose symptoms might remain sub-clinical or even be absent. In contrast, series of patients with severe PHPT report multiple end-organ failures including suppressed haematopoiesis (Horm Metab Res 1997; 29: 387) and marrow fibrosis (Clin Endo 2009; 70 :527).Aim: To determine the effect of parathyroidectomy on haem...

The purpose of the study was to assess the peculiarities of diagnostic and treatment of thyroid cancer in children.Material and method: Between 2000–2005 we screened 234 patients age 3–18 years that presented for various complaints suggesting possible thyroid disease (thyroid enlargement, dysphonia, dysphagia, delayed growth). They were submitted to clinical examination, ultrasonography, T4 and TSH test. The solitary nodules and polinodular goi...

We have studied 5 cases of insulinomas presented in our clinic in 2004–2005 with typical signs and symptoms of hypoglycemia correlated with high insulinemia. The medium insulin value in the morning was 57.9 mUI/ml, but we found values ranging from 10–98 mUI/ml for medium and severe hypoglycemia. There was no correlation between severity of hypoglycemia and insulin level, proven by repeated insulin dosages.The purpose of our analysis was to iden...

Background: There are two types of thyroid nodule biopsy: fine-needle aspiration (FNAB) and core-needle (CNB). Multiple studies mainly from Eastern Asia demonstrate safety and efficacy of CNB, however it is very rarely used in Europe.Methods: Retrospective analysis of the first 281 CNBs performed in Romania, including 8 lymph nodes and 3 thyroid bed lesions. We used the Korean Thyroid Association reporting system (KTA-CNB) for histology reports.<p cl...

Introduction: The significant increase in the average lifespan of the general population lead to a proportional enhancement in the prevalence of benign and malignant thyroid conditions and equally the number of surgeries for this pathology.Patients and method: In a personal series of 464 thyroid disorders undergoing surgery over two decades we recorded 51 patients (21.5%) aged over 65 years of which 11 (2.4%) having over 75 years. Demographic, clinical a...

Background: Chronic inflammatory processes of the thyroid represents an important proportion of the gland’s pathology but the majority of them must be treated by nonsurgical methods, thyroidectomy remaining circumstantially indicated.Patients and methods: In 14 cases (3%) from 464 operations for different thyroid lesions lesions we have encountered authentic inflammatory processes in nine cases of Hashimoto’s thyroiditis (two associated with pa...

Background: The optimal surgical technique in patients with refractory renal hyperparathyroidism (RHP) on hemodialysis for end stage renal disease is still a point of debates.The high percentage of recurrences after standard surgical procedures, i.e. subtotal parathyroidectomy (SPtx) and total parathyroidectomy with autotransplantation (TPtx+At) reactualised the practice of total parathyroidectomy (TPtx).Patients and methods: Forty...

Background: Renal hyperparathyroidism (RHPT) is a frequent complication of uremic patients on hemodialysis and despite various advances in medical therapy parathyroidectomy is necessary in a semnificative number of cases.Patients and methods: We reviewed our experience (first in Romania) regarding thirtyfour patients with RHPT operated on in our clinic between 1994 and 2007 evaluating the diagnosis methods, surgical indications, techniques and results to...

The hepatic autoimmune diseases are rarely associated with type 2 diabetes mellitus (T2DM). Instead, it’s more often encountered in people with type 1 diabetes mellitus in the context of polyglandular autoimmune syndrome (PAS). A 64-years old female diagnosed with T2DM for 8 years, hypertension and dyslipidemia currently under treatment with Dapagliflozin/Metformin 50/1000 mg twice daily, presented for her periodic diabetes consult complaining of marked fatigability and a...